Kidneys might be the secondary target of SARS-CoV-2 after the respiratory tract regardless of the previous history of kidney disease as indicated from the second-highest SARS-CoV-2 viral load found in the kidneys of the autopsy in COVID-19 death cases, preferably the glomerulus, which was associated with the richness of protein-coding genes including angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and cathepsin L (CTSL) in the kidney [11]. The gene discussed is CTSL; the disease is COVID-19.