Lanoiselée Lanoiselée H-M H-M Nicolas Nicolas G G Wallon Wallon D D APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases PLoS Med PLoS Med 2017 2017 14 14 e1002270 e1002270 10.1371/journal.pmed.1002270 10.1371/journal.pmed.1002270 supplied-pmid 28350801? The gene discussed is PSEN2; the disease is early-onset autosomal dominant Alzheimer disease.