Cortisol can reduce the proliferation and differentiation of osteoblasts, promote the apoptosis of osteoblasts and osteoblasts, increase the excretion of calcium in urine, and reduce the absorption of calcium in the small intestine, all of which will lead to a decrease in bone density and thereby increase the risk of osteoporosis.[42] Different from cortisol, growth hormone can act on osteoblasts and osteoclasts respectively to promote bone formation and absorption to play a role in bone remodeling and finally achieve the effect of bone accumulation. The gene discussed is GH1; the disease is osteoporosis.