Although the mechanism of hypertension-related osteoporosis is still unclear, the benefits of angiotensin-converting enzyme inhibitors (ACEI) and angiotensin-converting enzyme inhibitors (ARB) in increasing bone mass and reducing fracture risk have been reported.[24,25] Furthermore, angiotensin II receptor have been found expressed in osteoblasts,[26] which indicate that renin-angiotensin system is directly regulating the osteoblast activity and it is one of the vital mechanisms in hypertension-related osteoporosis. The gene discussed is REN; the disease is Hypertension.