HAND2 and lung adenocarcinoma: And lncRNA LINC00665 could enhance the proliferation and invasion ability of lung adenocarcinoma cells via absorbing mir-98 and being involved in ERK signaling pathway.[28] The lncRNA NR2F1-AS1 was the second degree in the ceRNA network, which could indirectly interact with the mRNAs FBN1, GALNT16, HAND2, and MCAM via hsa-mir-140, hsa-mir-139, and hsa-mir-141.