Several studies have explored the relationship between CAV1 polymorphisms and susceptibility to breast cancer,[7] esophageal carcinoma,[8] colorectal cancer,[9] gastric cancer,[10,11] hepatocellular,[12] and other cancers.[13,14] However, the results of the CAV1 rs7804372 (T29107A) polymorphism and susceptibility to digestive cancer remain controversial. This evidence concerns the gene CAV1 and cancer.