From a total of 32 variables, only 2 were directly linked with BDG (i.e., first neighbors in PGM): TNFR1, a predictive biomarker for the hyperinflammatory subphenotype, and ST-2, the soluble receptor of IL-33 that functions as an alarmin released by respiratory epithelia during acute lung injury (Figure 3C and ref. 35). The gene discussed is TNFRSF1A; the disease is injury.