Moreover, integrative analyses of clinical and biomarker variables with PGMs revealed 4 first neighbors of BDG: 2 clinical variables (diabetes and platelets) and the same 2 biomarkers (TNFR1 and ST-2) as in the ARF cohort (Supplemental Figure 12C), offering independent validation for the involvement of BDG in host inflammation. This evidence concerns the gene TNFRSF1A and diabetes mellitus.