While these studies support the idea that inflammatory responses induced by acute malaria have a detrimental impact on the TFH pool, recent findings in mice identified TH1 memory CD4+ T cells induced in response to infection capable of successfully sustaining B cell help (32), thus challenging the notion that TH1-polarized CD4+ T cells impair the development of long-lived antibody-mediated immunity. Here, CD4 is linked to malaria.