Linear regression analysis of the MBC compartment revealed that whereas class-switched classical MBCs expressing low levels of CXCR5 and CCR6 were overrepresented in healthy immune controls relative to P. vivax symptomatic and asymptomatic infected participants, their IgM+IgD+ counterparts, expressing high levels of these chemokine receptors, were more abundant in individuals carrying an infection (Figure 3F). The gene discussed is CD40LG; the disease is infection.