PTEN and posterior cortical atrophy: CXCL8 stemming from PTEN deficiency has been demonstrated to both augment autocrine CXCR4/7 and CCR2 expression in human PCa cells and instigate the paracrine release of their cognate ligands, CXCL12 and CCL2, by prostate stromal fibroblasts and monocytes (Maxwell et al. 2014).