CDK12 and posterior cortical atrophy: Although implicated in homologous recombination, cyclin-dependent kinase 12 (CDK12)-mutated PCa is genomically and immunologically distinct from HRD PCa, with limited PARP inhibitor responsiveness, high levels of genomic rearrangements, high neoantigen burden (second only to dMMR PCa) and increased lymphocytic infiltration (Antonarakis et al. 2020, Rescigno et al. 2021).