CXCL8 stemming from PTEN deficiency has been demonstrated to both augment autocrine CXCR4/7 and CCR2 expression in human PCa cells and instigate the paracrine release of their cognate ligands, CXCL12 and CCL2, by prostate stromal fibroblasts and monocytes (Maxwell et al. 2014). The gene discussed is CXCR4; the disease is posterior cortical atrophy.