First, pretreatment with LA14 alleviated the d-GalN-induced upregulation of the transcription of 13 genes in the liver, including biomarkers of cytokine secretion (Lilrb4 and Ackr3), cell carcinoma growth (Rock2, Socs5, Serpine1, Plau, Plod2, and Col12a1), cardiovascular disease (Adamts4 and Adamts9), stress (Fkbp5), bone development (Bmp2k), and lipid metabolism (Lpl) (Fig. 4A). Here, ADAMTS4 is linked to cardiovascular disorder.