HPN and cancer: Second, pretreatment with LA14 also relieved the d-GalN-induced downregulation of the transcription of 22 genes: most of these genes are involved in immunity regulation (MstI, Ifi27, and Aspg), cancer suppression (Ftcd, Hpn, Pck1, Mat1a, Tdo2, and Clk1), and lipid metabolism (Eci1, Creb3l3, Fabp1, and Hsd17b13), and some of the genes are relevant to reduced secretion of hepatic bile acid (Cyp2f4 and Cyp2d1), increased detoxification (Sult2a2 and Ugt2b15), iron homeostasis (Tfr2), antiaging (Rplp2), antioxidant activity (Sod1), and urinary excretion (Uox).