SPRYD4 and metabolic syndrome: Second, LA14 also relieved the d-GalN-induced downregulation of 34 hepatic proteins, which consisted of tumorigenesis factors (GTF2B, SDC4, TBRG4, COX7C, FBL, TOD2, LIN7A, MAP4K5, GRB7, SPRYD4, VAPA, and SEC24A), immunosuppression factors (DNAJA1, GLDC, CMC2, and TIAL1), energy-related factors (LRPPRC, ABCB4, MT-ND5, ABCC6, ATP5MG, and ARMC1), and proteins related to dyslipidemia (LDLRAP1, ECHDC3, PTGES2, and PI4KA), oxidative stress (SOD1), ion channel dysfunction (KCTD6), and other unknown physiological reactions (SPRYD7, BAIAP2, LYSMD3, and RGD1564854).