Hepatocyte- and macrophage-specific PPARγ deficiency protects Lep < ob/ob> mice from hepatic steatosis (Matsusue et al., 2003; Morán-Salvador et al., 2011); knockdown of Mogat1 in the liver significantly attenuates hepatic steatosis after 12 weeks HFD feeding (Lee et al., 2012); and restoration of Cidec/Fsp27 in Lep < ob/ob> liver-specific Pparg knockout mice promotes hepatic steatosis (Matsusue et al., 2008). The gene discussed is PPARG; the disease is fatty liver disease.