Inhibition of SUMO-1 by ginkgoic acid alleviated myocardial infarction-induced heart dysfunction and fibrosis, and the SUMOylated PML/Pin1/TGF-β1 pathway is crucial for ginkgoic acid-inhibited cardiac fibrosis, wherein Pin1 functions as a positive regulator of TGF-β1 mRNA (Qiu et al. 2018). Here, PIN1 is linked to myocardial infarction.