BAFF is upregulated in lesional keratinocytes in individuals with cutaneous lupus erythematosus, and upregulation of BAFF/BAFF-R signaling potentially influences the biological activity of endothelial progenitor cells in systemic lupus erythematosus (SLE) (Jackson and Davidson, 2019). The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.