Furthermore, although neurofibrillary tangles (NFTs) in AD, CTE, and primary age-related tauopathy (PART) [6, 8, 43] incorporate all six Tau isoforms, the fold of the core of Tau filaments is identical in AD and PART and different from that in CTE [12, 16, 55]. The gene discussed is MAPT; the disease is Alzheimer disease.