In Prion-Protein Cerebral Amyloid Angiopathies (PrP-CAA), which are associated with nonsense mutations in the PRNP gene [21, 22, 37], the main histologic feature is the co-existence of numerous intraneuronal Tau aggregates with APrP in the vascular compartment. Here, PRNP is linked to cerebral amyloid angiopathy.