GSS and Alzheimer disease: We also observe PTMs that have been reported to be important in Tau fibrillization and propagation in AD [27, 28], for example, phosphorylation at T231, thought to be central to the initial steps of Tau detachment from microtubules and subsequent aggregation [1, 2], is found in our cases of AD, PrP-CAA (Q160X) and GSS (F198S).