HIF1A and cancer: The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of the repressed genes showed that these down-regulated genes were mainly enriched in the following pathways including mitogen-activated protein kinase MAPK signaling pathway, cAMP signaling pathway, HIF-1α signaling pathway, Ras signaling pathway, and cytokine-cytokine receptor interaction, which were known to be important in cancer (Figure 6F).