WNK2 and neoplasm: Here, we identified an 11-lncRNA model that was associated with tumor OS in ESCC patients, constructed a lncRNA-based molecular subtype of ESCC, and found that lncRNA AC007128.1 might mediate ESCC EMT through mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) and MAPK/p38 signaling pathways.