In addition, overexpression of YAP significantly sped up DNA repair (using DNA–PKcs and Rad51 levels as indicators) and the cell cycle (using CDK4, CDK6, p-RB, and PCNA levels as indicators), while a reduction in DNA damage (using the p-H2AX level as an indicator) and apoptosis (using cleaved PARP and Bax levels as indicators) was observed in U87 (Fig. 3I) and U251 glioma cells (Fig. 3J). Here, CDK4 is linked to central nervous system cancer.