Together, results from in vivo mouse model studies in Fig. 5A–D are in agreement with the in vitro cell lines studies and demonstrated that targeting the circRNA-ARC1 could suppress the Enz-increased PCa metastasis via altering the circRNA-ARC1/miR-125b-2-3p/miR-4736/PPARγ/MMP-9 signals (see outline in Fig. 6). This evidence concerns the gene CDH1 and posterior cortical atrophy.