Our findings here that ADT-Enz (or AR-shRNAs) may function via differentially altering the AR-encoded circRNA-ARC1 to increase PCa metastasis, yet decrease BCa metastasis, not only may help treatment to improve the ADT-Enz therapy efficacy via reducing those adverse effects, it may also represent the first evidence to link AR-encoded circRNAs to the differential anti-AR therapies. The gene discussed is AR; the disease is posterior cortical atrophy.