The linkage of these AR gene-coded circRNAs to the differential effects on the cell invasion of prostate cancer (PCa) vs. bladder cancer (BCa) in response to androgen-deprivation therapy (ADT) with the antiandrogen Enzalutamide (Enz) treatment (ADT-Enz), however, remains unclear. The gene discussed is AR; the disease is urinary bladder carcinoma.