Together, results from Fig. 2A–E suggest that AR may play a positive autoregulation role in BCa via binding to ARE1 while a negative autoregulation role in PCa via binding to ARE2, and these opposing autoregulation roles may then result in increasing the circRNA-ARC1 expression in PCa cells, yet decreasing its expression in BCa cells. The gene discussed is AR; the disease is posterior cortical atrophy.