Importantly, interruption approaches via adding shRNA to suppress the circRNA-ARC1 led to partially reverse the AR-shRNA-increased cell invasion in PCa C4-2 and CWR22Rv1 cells (Fig. 2F), while partially reversed the AR-increased cell invasion in BCa T24 and TCC-SUP cells (Fig. 2G). This evidence concerns the gene AR and posterior cortical atrophy.