To study the consequences of differentially regulating the circRNA-ARC1 expression induced by targeting androgen/AR in the PCa vs. BCa, we applied the matrigel-coated transwell invasion assay, and results revealed that decreasing fAR (shAR) led to increase cell invasion in both PCa C4-2 and CWR22Rv1 cells (Fig. 2F), yet increasing fAR (OEAR) led to increase cell invasion in both BCa T24 and TCC-SUP cells (Fig. 2G). The gene discussed is AR; the disease is tarsal-carpal coalition syndrome.