It is likely the tumor origin of tissues as well as cellular signaling networks in the PCa vs. BCa are different so that AR may associate with different co-factors/co-repressors to form distinct complexes that result in binding to different AREs in the AR locus, and consequences of such differential binding may then result in a positive autoregulation in BCa cells vs. a negative autoregulation in PCa cells. The gene discussed is AR; the disease is posterior cortical atrophy.