Further mechanistic analysis revealed that Enz/AR/AR-encoded circRNAs signaling might function via sponging/altering the expression of miR-125b-2-3p and/or miR-4736 to influence the metastasis-related PPARγ/MMP-9 signals to impact the PCa vs. BCa cell invasion. Here, MMP9 is linked to posterior cortical atrophy.