It will be interesting in the future to see if targeting this newly identified AR/circRNA-ARC1/miR-125b-2-3p/miR-4736/PPARγ/MMP-9 signaling with small molecules (for example, shRNA of circRNA-ARC1 as shown in our in vivo mice data) may help in the development of novel therapeutic approaches to increase the Enz efficacy with less adverse effects to better suppress metastases in patients with PCa and BCa. Here, PPARG is linked to posterior cortical atrophy.