After adjustment of age, gender, body mass index, etiology, hypertension, diabetes mellitus, white blood cell, C-reactive protein, procalcitonin, alanine aminotransferase, total bilirubin, blood urea nitrogen, serum creatinine, PaO2/FiO2, systolic blood pressure, intra-abdominal hypertension, BISAP score, total fluid, time of blood volume expansion, modified Marshall Score , binary logistic regression analysis revealed that patients used pure water for FRVC had 0.077 times more likely to develop hypernatremia (95% CI 0.007–0.853, P = 0.037) (Table 6). The gene discussed is CRP; the disease is Hypernatremia.