PSEN1 and Alzheimer disease: We tested our MEMRI technique in two rodent models of AD.The well-characterized 5xFAD transgenic mouse model of AD, which express human APP with the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations and human PSEN1 with the M146L and L286V mutations and start developing Aβ plaques from as early as two months of age15.