KDM5D and neoplasm: We show here that transcript abundance of KDM5C differs significantly between male tumours exhibiting low KDM5D expression (≥ 1.5 SD below the overall male mean) and male tumours lacking this feature (n 65, two-sided W = 181, difference in location − 0.21[95% CI − 0.34, − 0.06], P = 0.0091), with low KDM5D expressing tumours exhibiting relatively raised KDM5C. These data contrast with cardiomyocytes, where KDM5D knockdown has no discernible impact on KDM5C levels26, and indicate a degree of active regulation of the dosage balance between these gametologs in the lung.