Finally, the COL2A1 gene encodes collagen type II alpha 1 chain; mutations in this gene can cause Stickler Syndrome Type 1 which is a heterogeneous group of collagen tissue disorders, characterized by orofacial features, and ophthalmological features such as high myopia, vitreoretinal degeneration, retinal detachment, and presenile cataracts56,57. This evidence concerns the gene COL2A1 and retinal detachment.