Studies show that the abnormal structure or expression of RBPs is one of the most common pathological changes in AD, for example, fused in sarcoma (FUS), polyglutamine-binding protein 1 (PQBP1), TAR DNA-binding protein (TDP-43), etc. All these studies recognized the importance of RBPs in AD [12–14]. The gene discussed is TARDBP; the disease is Alzheimer disease.