The experiment results show that ACTBP2 promotes the interaction between KMT2D and WDR5, recruits KMT2D/WDR5 to the KHDRBS2 promoter, generates H3K4me3 in KHDRBS2 promoter, and promotes the transcription of KHDRBS2 in AD environment. Here, ACTBP2 is linked to Alzheimer disease.