For example, in the human umbilical vein ECs (HUVECs) in rheumatoid arthritis model, bonding of RBP TTP and intercellular cell adhesion molecule-1 (ICAM-1) mRNA 3′UTR decreases the stability of ICAM-1, reduces the expression of ICAM-1 in HUVECs, and participates in the inhibition of inflammatory response of rheumatoid arthritis [47]. This evidence concerns the gene ICAM1 and rheumatoid arthritis.