In addition, a panel of Alzheimer’s-disease relevant genes, which are consistently up-regulated in the transgenic CRND8 mouse brain over time, also reveals variable (Abi3 versus Plcg2)—and sometimes unexpected (Trem2)—responses to Aβ peptides in microglia (Fig 6D). This evidence concerns the gene PLCG2 and early-onset autosomal dominant Alzheimer disease.