In addition, a panel of Alzheimer’s-disease relevant genes, which are consistently up-regulated in the transgenic CRND8 mouse brain over time, also reveals variable (Abi3 versus Plcg2)—and sometimes unexpected (Trem2)—responses to Aβ peptides in microglia (Fig 6D). The gene discussed is TREM2; the disease is early-onset autosomal dominant Alzheimer disease.