APOE and Brain atrophy: Our result is in line with our previous report showing that in EOAD APOE ε4 carriers had less severe brain atrophy in the frontal and perisylvian areas compared to APOE ε4 noncarriers while in LOAD APOE ε4 carriers showed more severe brain atrophy in the medial temporal area compared to APOE ε4 noncarriers [3].