Considering the presynaptic mechanisms, inhibitory interneurons in CA1 local circuits may contribute to network dysfunction under AD conditions, as dysfunction of parvalbumin-positive inhibitory interneurons [3, 41] and oriens-lacunosum-moleculare (O-LM) inhibitory interneuron [42] has been found to be involved in memory impairment in amyloidosis AD models. This evidence concerns the gene PVALB and memory impairment.