The multivariate Cox regression analysis showed that T stage (P < 0.05), lymph node metastasis (P < 0.05), distant metastasis (P < 0.01), NCX3 expression (P < 0.05), and NCX1 and NCX2 expression (P < 0.01) were independent prognostic factors of CC (Table 2). This evidence concerns the gene SLC8A3 and metastatic malignant neoplasm in the lymph nodes.