In addition, the decrease or loss of NCLX expression can cause mtCa2+ overload, which leads to mitochondrial depolarization, increases mtROS production, initiates the mitochondrial Ca2+/ROS signaling axis to drive HIF1a activation and HIF1a-dependent glycolysis, promoting the migration, invasion, and metastasis of colorectal cancer cells [54]. Here, HIF1A is linked to colorectal cancer.