TLX2 and colonic neoplasm: Fourbon Y found that the upregulation of the voltage-gated Ca2+ channel (CaV) Ca2+ protein α1D can reduce the excretion of Ca2+ and increase [Ca2+]i by downregulating NCX1/3, leading to the proliferation and migration of the HCT116 colon cancer cell line; moreover, the use of the NCX inhibitor SEA0400 significantly promoted the migration of CRC cells [35].