High expression of HMMR (P = 5.0e-9), FN1 (P = 1.0e-6), CCNB1(P = 9.5e-7), CXCL8(P = 1.5e-5), MAD2L1(P = 2.4e-8), CCNA2(P = 9.9e-8) were correlated with significantly worse OS in GC patients, while SPP1 expression was not relevant to survival (P = 0.2713). This evidence concerns the gene SPP1 and gastric cancer.