The present study aimed to further assess the association of 13 SNPs (i.e., rs2274976, rs1801133, rs535107, rs4846052, rs1476413, rs4846048, rs4846051, rs1931226, rs2066470, rs3737964, rs7525338, rs1801131 and rs1889292) of maternal MTHFR gene with risk of CHD and its three subtypes in offspring. The gene discussed is MTHFR; the disease is coronary artery disorder.