The enrichment analysis highlighted that the predictions were enriched for genes associated with biological processes known to be affected by the ALS pathogenesis, such as angiogenesis (53), lipid metabolism (54), mitochondria activity (55), protein kinase activity (56), superoxide metabolism (57,58), vesicle-trafficking (59), neurotransmitter regulation (60), and with other neurodegenerative diseases for which evidence of phenotypic and genetic overlap with ALS exist, such as Charcot-Marie-Tooth disease, Parkinson′s disease, Frontotemporal dementia, Schizophrenia and Alzheimer's Disease. The gene discussed is WEE1; the disease is early-onset autosomal dominant Alzheimer disease.