Furthermore, nine mutated genes (CHD4, COL2A1, COL4A2, COL9A2, EGF, ITGB4, TERT, TLR3, TNXB) belonged the same pathway of the Human papillomavirus infection (hsa05165) according to KEGG over-representation analysis. Here, ITGB4 is linked to human papilloma virus infection.