AK2 and hepatocellular carcinoma: Knockout of the AK2 gene in Huh7, a hepatoma cell line, resulted in a significant reduction in RDV anti-SARS-CoV2 activity, indicating that AK2 is involved in RDV activation (E. Akinci, M. Cha, L. Lin, G. Yeo, M. C. Hamilton, C. J. Donahue, H. C. Bermudez-Cabrera, L. C. Zanetti, M. Chen, S. A. Barkal, B. Khowpinitchai, N. Chu, M. Velimirovic, R. Jodhani, J. D. Fife, M. Sovrovic, P. A. Cole, R. A. Davey, C. A. Cassa, and R. I. Sherwood, personal communication).