IL‐15 activated IELs acquire cytotoxic properties by upregulating natural‐killer group 2 member D (NKG2D) receptor, responsible for epithelial cell damage, leading to dysregulated immune responses at intestinal mucosa in celiac disease (Qingsheng et al, 2006; Valérie & Bana, 2014). The gene discussed is IL15; the disease is celiac disease.