Serum samples of celiac disease high‐risk subjects positive for anti‐tissue transglutaminase immunoglobulin A antibodies (anti‐tTG IgA) or/and anti‐deamidated gliadin peptide immunoglobulin G antibodies (anti‐DGP IgG)] and double‐negative subjects (anti‐tTG IgA− anti‐DGP IgG−) were obtained. This evidence concerns the gene TGM2 and celiac disease.