CD4 and small intestine enteropathy: In order to evaluate intestinal CRAMP expression and its effect on gluten‐induced small intestinal enteropathy, a mouse model of GIE by adoptive transfer of gliadin‐presensitized CD4+CD45RBlowCD25− T cells into lymphopenic Rag1−/− mice, recapitulating intestinal pathology of human celiac disease (Freitag et al, 2009) was applied (Fig 1A).