On the other end of the spectrum, late immunogenic surveillance is characterized by low baseline CD3+, CD8+ T cell infiltration, and, in this scenario, there is no selective pressure to evade, but the high mutation rate generates increased neoepitopes (via FSPs), resulting in increased MHC class I presentation, leading to cytotoxic T cell activation and upregulation of PD-L1 inhibitory signals by tumor cells, and thus potentially leading to T cell exhaustion [37, 76]. This evidence concerns the gene CD8A and neoplasm.