Hypertension: treated ≥140/90 mm Hg ACEi, AT1 receptor antagonist, CCB, BB, thiazide diuretic,27HF: ACEi, AT1 receptor antagonist, BB, thiazide diuretic, spironolactone, loop diuretic,28CAD: ACEi, AT1 receptor antagonist, CCB, BB, aspirin, statins, other LL drugs,29diabetes: lifestyle modifications, insulin therapy, oral antidiabetic drugs30. The gene discussed is INS; the disease is Hypertension.