INS and obesity due to melanocortin 4 receptor deficiency: According to 2016 ESC AF guidelines26: hypertension: controlled <140/90 mm Hg, MI: initially short period of triple therapy (OAC, aspirin, and clopidogrel) reducing to double (OAC and aspirin or clopidogrel), HF: ACEi or ARB along with BB, digoxin, and diuretic, PAD: statins or ACEi/ARB, stroke/TIA: withdraw OAC for short period depending on stroke severity and consider switching OAC if stroke while on OAC, diabetes: diet, insulin therapy, oral antidiabetic drugs, obesity: BMI < 30 kg/m2