Hypertension: active management of ≥160/90 mm Hg with ARB, ACEi, BB, or mineralocorticoid receptor antagonist,32HF: ACEi or ARB along with BB along with further considerations,33diabetes: lifestyle modification, glucose control, insulin, and metformin first-line therapy for T1D and T2D, respectively34. The gene discussed is INS; the disease is type 2 diabetes mellitus.