According to unspecified guidelines: hypertension: controlled <140/90 mm Hg, HF: ACEi or ARB along with BB, MI: ACEi or ARB along with BB and LL drugs, PAD: LL drugs, diabetes: oral anti-diabetics or insulin, obesity: BMI < 30 kg/m2. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.