According to 2016 ESC AF guidelines26: Hypertension: controlled <140/90 mm Hg, HF: ACEi or ARB along with BB, digoxin, and diuretic, PAD: statins or ACEi/ARB, CAD: ACEi or ARB along with BB, aspirin or clopidogrel, and LL drugs, stroke/TIA: withdraw OAC for short period depending on stroke severity and consider switching OAC if stroke while on OAC, diabetes: diet, insulin therapy, oral antidiabetic drugs. The gene discussed is INS; the disease is Stroke.