The expression of ACTB, ACTG1, ACTN4, ACTR2, ACTR3, ANLN, AP2A1, ARPC4, CAPZA2, CAPZB, CFL1, CLTA, CLTB, CORO1B, CORO1C, DAB2, DBN1, EPS15, FLNA, FLNB, INF2, IQGAP1, LIMA1, MYH9, MYO18A, MYO5A, SPTAN1, SPTBN1, SVIL, SYNPO, TMOD3, TPM1, and WDR1 were significantly increased in PAAD tissue (P < 0.05) (Supplementary File 3). This evidence concerns the gene SYNPO and pancreatic adenocarcinoma.