We evaluated whether CCND1/IGH FISH complexity was associated with an increased incidence of TP53 deletion, MYC rearrangement, or tetraploidy.TP53 deletion is associated with increased genomic complexity and poorer outcome in both PCN and MCL, including an association with the more highly proliferative blastoid and pleomorphic variants of MCL.1, 3, 20. Here, MYC is linked to mantle cell lymphoma.