BCL2 and neoplasm: While combined Src/Bcl-2 inhibition was a superior therapy to target stem-like cellscompared to Src inhibition alone, this treatment was still more effective inanchorage-independent conditions, suggesting that the additional stress enhances response.The ability of tumor cells to grow anchorage-independent tumorspheres is a routinely used invitro assay to monitor stemness and predictor of metastatic potential.