These molecules detect infection-derived ligands through their extracellular/luminar domain known as leucine-rich repeats (LRRs) and signal through their cytosolic conserved region known as toll-like/interleukin-1 receptor (TIR) homology domain to trigger the downstream signaling adaptor proteins such as myeloid differentiation primary response gene 88 (MyD88) [3]. Here, MYD88 is linked to infection.