Factors that could justify retinal perfusion worsening following VEGF inhibition include inducing vasoconstriction of the retinal vasculature which was found following bevacizumab and ranibizumab injections for DME possibly due to nitric oxide inhibition which occurs with VEGF inhibition and also leads to systemic hypertension in case of systemic VEGF inhibition [62, 63]. Here, VEGFA is linked to Hypertension.