VSIG4 and liver dysplastic nodule: Besides, VSIG4 is a B7 family-related protein and acts as a complement receptor for C3 [57]; it has been reported that VSIG4 can induce the epithelial-mesenchymal transition of renal tubular cells when exposing to high-glucose condition [58], but how VSIG4 affect DN through the complement system is still unknown.