ICAM1 and cancer: This part of results revealed that PDCD1 [36], ICAM1 [37], and GZMA [38], which were associated with proactivity of cytotoxic T lymphocytes and cancer immunity, were predictive of prolonged prognosis in the low pIRS group, and VEGFA, as the leading molecule of tumor-induced angiogenesis for tumor invasion [39], exhibited an increased expression in breast cancer patients with limited survival of patients from the high pIRS group.