Similarly, another study showed that macrophage LRP deletion in the LDLR-deficient mouse model enhanced atherosclerosis development and increased monocyte chemoattractant protein type-1 (MCP-1), TNFα, and matrix metalloproteinase-9 (MMP-9) levels as well as proximal aorta macrophage cellularity (36). This evidence concerns the gene TNF and atherosclerosis.