LRP1 and atherosclerosis: The binding of PDGF, a potent mitogen for fibroblasts and VSMCs, to PDGF receptor β (PDGFRβ) activates a signaling pathway that promotes VSMs growth and migration, which are crucial in atherosclerosis and neointima formation and LRP1 has been proven to suppress this process through incompletely understood mechanisms (14, 24, 33, 121, 173–175).