Through its ECD, LRP1 can bind with high affinity and internalize more than 75 distinct, structurally and functionally unrelated ligands, such as proteins involved in lipoprotein metabolism and transport (30, 31, 59, 102–105), proteins involved in AD (59, 90, 91, 106), proteases and protease/inhibitor complexes (27, 31, 34, 57, 107–120), growth factors (121–123), extracellular matrix proteins (124–126), infection (127–130), transcription activation (131), chaperones (132–136), blood coagulation (137, 138) and others (103, 139–157) (Table 1). The gene discussed is LRP1; the disease is Alzheimer disease.