Thus, based on the broad spectrum of ligands that it recognizes, LRP1 participates in multiple physiological and pathological processes, including lipid and glucose metabolism, protein degradation, wound healing and tissue repair, cell differentiation, hepatic steatosis, kidney fibrosis, acute respiratory distress syndrome (ARDS), Alzheimer's disease, tumor growth and progression, atherosclerosis, and inflammation (10, 64, 68, 159, 162). The gene discussed is LRP1; the disease is atherosclerosis.