Adipose tissues have been shown to exhibit increased inflammation with enhanced monocyte–macrophage infiltration and inflammatory gene expression in mice with adipocyte-specific LRP1 knockout (adLRP1–/–) in PVAT, and that mice transplanted with PVAT from adLRP1–/– mice displayed a 3-fold increase in atherosclerosis compared to those transplanted with PVAT from adLRP1+/+ mice after a western diet (98). The gene discussed is LRP1; the disease is atherosclerosis.