The effect of LRP1 on the progression of atherosclerosis has been tested in ApoE–/– and LDLR–/– mice, with the results showing that atherosclerosis development was enhanced in ApoE–/–, LDLR–/– and ApoE/LDLR double knockout mice harboring LRP gene deletions. The gene discussed is LDLR; the disease is atherosclerosis.