Strong evidence has emerged for Kdm6a and Kdm5c (Lysine-specific demethylase 6a and 5c), two X-linked genes and Uty/Kdm6c (Lysine-specific demethylase 6c), a Y-linked gene, as candidates for contributing to sex differences in mouse models of cancer, autoimmunity, metabolic disease and Alzheimer's (54–57). This evidence concerns the gene KDM6A and Other metabolic disease.