In addition, as for heart failure indexes, LVEF [mean (SD): 51.8 (10.6)% vs. 52.0 (10.7)%, p = 0.898] and BNP [mean (SD): 463.6 (529.3) ng/ml vs. 555.5 (841.7) ng/ml, p = 0.288] did not differ between sulfonylurea users and non-sulfonylurea users (Table 2). This evidence concerns the gene NPPB and heart failure.