Also, hyperglycemia in DM individuals, independently, or secondarily to the presence of diabetic complications, increases the risk of SARS-CoV-2 infection in different ways, including an increased affinity from SARS-CoV-2 to ACE2, reduction of viral clearance, T cell-mediated immunity dysfunction, and CS induction (51). This evidence concerns the gene ACE2 and Hyperglycemia.