Accordingly, in this study, we used gene expression information for eight PCa-related pathways (i.e., hypoxia, androgen response, PI3K-AKT-mTOR signaling, E2F targets, MYC targets V1, MYC targets V2, glycolysis, fatty acid metabolism, and oxidative phosphorylation pathways) extracted from Molecular Signatures Database v7.2 and data for PCa cohorts from multiple platforms (TCGA, GSE70769, DKF 2018, and MSKCC 2010) to identify three PCa subtypes (Risk_H, Risk_M and Risk_L). This evidence concerns the gene AKT1 and posterior cortical atrophy.