The luciferase test results suggest that the CRISPReader can significantly activate the expression of luciferase in BGC-823, RPMI 1640, and HGC-27 gastric cancer cell lines that highly express Ets-1, while it cannot express luciferase in normal gastric epithelial cells GES-1 (Figure 3). This evidence concerns the gene ETS1 and gastric cancer.