NR3C2 and Hypertension: Although treatment with VPA not only enhanced MR acetylation but also increased histone-3-acetylation (H3Ac) and trimethylation (H3K4me3) in the promoter regions of MR target genes, expression of MR target genes was decreased, and the development of hypertension in deoxycorticosterone acetate-induced hypertensive rats and spontaneously hypertensive rats (SHR) was prevented (Seok et al., 2016).