Furthermore, HDAC inhibition attenuated pathophysiological MR effects like hypertension, hypertrophy, inflammation and fibrosis in vivo in animal models of spontaneous hypertension and hyperaldosteronism (Cardinale et al., 2010; Iyer et al., 2010; Lee et al., 2013; Kang et al., 2015; Seok et al., 2016). Here, HDAC9 is linked to hypertensive disorder.