PEBP1 and early-onset autosomal dominant Alzheimer disease: Besides its role in normal physiological phenomena, dysregulated RKIP expression was observed to contribute significantly to pathophysiological illnesses including Alzheimer’s disease, various cancerous ailments and diabetic nephropathy (Keller et al., 2004; Escara-Wilke et al., 2012; Ling et al., 2014; Farooqi et al., 2015).