Downregulation of RKIP has also been observed in pathologies like diabetic nephropathy, sperm decapitation, heart failure, Alzheimer’s disease and lung-related pathologies (Keller et al., 2004; Klysik et al., 2008; Raquel-Cunha et al., 2019). This evidence concerns the gene PEBP1 and early-onset autosomal dominant Alzheimer disease.