ELANE and chronic rhinosinusitis: Human neutrophil elastase induces MUC5AC overexpression in chronic rhinosinusitis through miR-146a (Yan et al., 2020). Furthermore, miR-27b-3p, miR-181a-1-3p, and miR-326-5p are involved in the inhibition of macrophage activation in chronic liver injury (Li et al., 2017).