Kober et al. (2011) identified the hypermethylation of BARX1 promoter in colorectal cancer. Besides, Becker et al. (2015) and Yan et al. (2018) revealed that BARX1 could increase the risk for the development of esophageal adenocarcinoma. Furthermore, Wang et al. (2017) provided reliable evidence that the loss of BARX1 could promote hepatocellular carcinoma metastasis and indicate poor prognosis. The gene discussed is BARX1; the disease is colorectal cancer.